DUTCH COMPLEMENT__

SYMPOSIUM 2018

23rd November
NUNSPEET

THE NETHERLANDS

Complement

Program

9:00 - 9:30
 
Arrival and registration

9:30 - 9:35
 
Opening

Dr Leendert Trouw (LUMC)

Session 1:
9:35 - 10:30
 
Keynote 1:

Dr Taku Fukuzawa (Chugai, Japan) Recycling Antibody Technology and Its Use in Targeting Complement C5

10:30 - 10:50
 
Invited Speaker

Dr Thom Sharp (LUMC) Visualizing IgM immune complexes interacting with C4b on membranes using cryoET

10:50 - 11:10
 
Break
Session 2:
11:10 - 11:30
 
Invited Speaker

Dr Mathijs Jore (Radboud UMC) Complement and Malaria

11:30 - 12:15
 
Presentation of selected Abstracts

1)  11.30 – 11.45 - Rosalie Lubbers Complement component C1q as serum biomarker to detect active tuberculosis   2) 11.45 – 12.00 - Dennis J. Doorduijn Molecular insights into the target-specific assembly of bactericidal MAC pores   3) 12.00 – 12.15 - Simone C. Oostindie CD20 and CD37 antibodies synergistically induce killing of malignant B-cells through complement-dependent cytotoxicity

12:15 - 13:15
 
Lunch & Posters
Session 3
13:15 - 14:00
 
Keynote 2

Prof Dr Admar Verschoor (University of Lübeck, Germany) Delivering the goods: roles for complement in antigen handling and the developing immune response

14:00 - 14:20
 
Invited speaker

Dr Ilse Jongerius (Sanquin Research) C1-INH used as evasion mechanism by pathogens

14:20 - 15:05
 
Presentation of selected Abstracts

4) 14.20 – 14.35 - Gillian Dekkers Increased alternative pathway regulation by using a complement regulator factor H potentiating antibody 5) 14.35 – 14.50 - Vojtech Franc Analysis of human serum glycoproteins by native chromatography and hybrid mass spectrometry approaches 6) 14.50 – 15.05 - Laura Lorés-Motta Genome-wide association study reveals genetic variants in CFH and CFHR4 associated with systemic complement activation: implications in age-related macular degeneration.

15:10 - 15:30
 
Break
Session 4:
15:30 - 15:50
 
Invited speaker

Christine Kramer (Sanquin, Amsterdam) Treatment of angioedema patients

15:50 - 16:35
 
Presentation of selected Abstracts

7) 15.50 – 16.05 - Ying Xin The alternative complement pathway is associated with an adverse lipid profile: The CODAM study 8) 16.05 – 16.20 - Sarah de Jong Expression levels of rare missense variants in CFI found in age-related macular degeneration, atypical uremic syndrome or both diseases 9) 16.20 – 16.35 - Iliana Michailidou Inhibition of C6 as a therapeutic strategy for neuroinflammation

16:35 - 16:55
 
Invited Speaker

Prof. Dr. Jack Wetzels (Radboud UMC) Treatment of complement-mediated renal diseases

17:00 - 17:05
 
Closing

17:05 - 18:30
 
Drinks & Posters