DUTCH COMPLEMENT__

SYMPOSIUM 2025

11th April
NUNSPEET

THE NETHERLANDS

DUTCH COMPLEMENT SYMPOSIUM 11th APRIL 2025

Program

9:00 - 9:30
 
Registration

9:30 - 9:35
 
Opening

Dr Leendert Trouw (LUMC)

Session 1:
Complement regulation
9:35 - 10:30
 
Keynote 1:

Elena Goichoechea de Jorge (Madrid, Spain)

10:30 - 11:00
 
Invited Speaker

Dr Felix Poppelaars (UMCG): Leveraging Complement Genetics to Enhance Long-Term Outcomes in Kidney Transplantation

11:00 - 11:20
 
Break
Session 2:
Complement structure and assays
11:20 - 11:35
 
Selected abstract 1

Christine Yanni (Genmab): The Role of Antibody Formats and Complement in Antigen Delivery to Dendritic Cells

11:35 - 11.50
 
Selected abstract 2

Karla I. de la O Becerra (UU): Insights into classical and lectin pathway C3 convertase

11.50 - 12.05
 
Selected abstract 3

Jolein Gloerich (RadboudUMC): Advancing Diagnostics for Complement-Mediated Diseases: A Mass Spectrometry-Based Approach for Comprehensive Complement Protein Quantitation in Plasma

12.05 - 12.20
 
Selected abstract 4

Tereza Kadavá (UU):Spider Chasing Its Prey: Structural Insights into Human Serum C4b-binding Protein and Its Complexes

12.20 - 13.05
 
Lunch & Posters
Session 3:
The complement system in therapy and disease
13.05 - 14.00
 
Keynote 2

Dr Inkeri Lokki (Helsinki, Finland): Complement in pregnancy

14.00 - 14.30
 
Invited speaker

Dr Josephine Vos (AUMC): The potential of complement inhibitors; the case of cold agglutinin disease and sutimlimab

14.30 - 14.45
 
Selected abstract 5

Sofie Rutjens (argenx): The story of empasiprubart (ARGX-117) a long acting inhibitory C2 antibody from bench to MMN patients

14.45 - 15.00
 
Selected abstract 6

Haiyu Wang (LUMC): Bispecific antibodies targeting endogenous complement inhibitors for targeted local complement inhibition in the context of rheumatoid arthritis

15.00 - 15.15
 
Selected abstract 7

Caroline Klaver (ErasmusMC): Effect of Pegcetacoplan on Aqueous Humor Proteome in Geographic Atrophy: A Prospective Exploration

15.15 - 15.35
 
Break
Session 4:
Complement in disease models
15:35 - 15:50
 
Selected abstract 8

Frank Baas (LUMC) : Combatting neuroinflammation by complement inhibition

15.50 - 16:05
 
Selected abstract 9

Juliette van Noort (CHDR) : Intradermal LPS as a human challenge model for pharmacodynamic evaluation of future complement-targeting drugs

16.05 - 16.55
 
Poster pitches

Session 5:
Posters
16:55 - 17:00
 
Closing

Leendert Trouw (LUMC)

17.00 - 18.30
 
Drinks & Posters

Posterviewing session

download program here